李广宇 【副教授】

姓名 李广宇 性别 照片
职称 副教授 学位 博士
电话 13407195245 邮箱 liguangyu@mail.hzau.edu.cn
工作单位 华中农业大学水产学院
研究方向 水毒理及环境健康评价
教育经历 教育经历(按时间倒排序):
2005/9 - 2010/7,中国科学院水生生物研究所,水生生物学,博士,导师:谢平
2001/9 - 2005/7,华中师范大学,生物技术,学士
主要职历 工作经历(科研与学术工作经历,按时间倒序排序):
2016/3-2017/3,加州大学戴维斯分校,访问学者
2012/12 - 至今,华中农业大学,水产学院,副教授
2010/7 
科研成果  

主持或参加科研项目及人才计划项目情况(按时间倒序排序):

 [1] 国家自然科学基金面上项目31570510微囊藻毒素的母代转移途径及其诱发子代神经毒性的机制研究2016/1-2019/12、资助金额:63.0万元、主持。

[2] 霍英东教育基金青年教师基金141078、《孕期微囊藻毒素暴露诱发胎鼠发育迟缓的分子机制》、2014/1-2015/12、资助金额:11.0万元、在研、主持。

[3] 国家自然科学青年基金31200402、《微囊藻毒素的母体传递效应对斑马鱼子代胚胎发育的影响》、2013/1-2015/12、资助金额:21.0万元、结题、主持。

[4] 教育部新教师基金20120146120008、《环境浓度微囊藻毒素暴露诱发斑马鱼子代胚胎发育毒性的分子机制》、2013/1-2014/12、资助金额:4.0万元、已结题、主持。

[5] 湖北省自然科学基金2011CDB151、《微囊藻毒素诱发斑马鱼胚胎细胞凋亡的分子机制研究》、2011/1-2012/12、资助金额:2.0万元、已结题、主持。

发表论文(第一及通讯作者):

[1] Wu Q, Yan W, Liu CS, Li L, Yu L, Zhao SJ, Li GY*. Microcystin-LR exposure induces developmental neurotoxicity in zebrafish embryo. Environ. Pollut. 213, 793-800.2016. [IF 4.88]

[2] He J, Li GY, Chen J, Lin J, Zeng C, Chen J, Deng J, Xie P. Prolonged exposure to lowdose microcystin induces nonalcoholic steatohepatitis in mice: a systems toxicology study. Arch. Toxicol. 91, 465-480. 2017. [IF 6.637]

[3] Li GY, Yan W, Dang Y, Li J, Liu CS, Wang J*. The role of calcineurin signaling in microcystin-LR triggered neuronal toxicity. ScientificReports, 5:11271. 2015. [IF 5.58]

[4] Li J, Giesy JP, Yu L, Li GY*, Liu CS*. Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Tetrahymena Thermophila: targeting the ribosome. Scientific Reports, 5:10562. 2015. [IF 5.58] 并列通讯

[5] Xie L, Yan W, Yu L, Wang J, Li GY*, Chen N*, Alan DS. Microcystin-RR exposure results in growth impairment by disrupting thyroid endocrine in zebrafish larvae. Aquat. Toxicol. 164:16-22. 2015. [IF 3.75] 并列通讯  

[6] Zhao SJ, Li G*, Chen J*. A proteomic analysis of prenatal transfer of microcystin-LR induced neurotoxicity in rat offspring. J. Proteomics 114: 197-213. 2015. [IF 3.92] 并列通讯

[7] Zeng C, Sun H, Xie P, Wang JH, Zhang GR, Chen N, Yan W*, Li GY*. The role of apoptosis in MCLR-induced developmental toxicity in zebrafish embryos. Aquat. Toxicol. 149: 25-32. 2014. [IF 3.73] 并列通讯  

[8] Li GY, Yan W, Cai F, He Y, Chen N, Wang JH*. Spatial learning and memory impairment and pathological change in rats induced by acute exposure to microcystin-LR. Environ. Toxicol. 29: 261-268. 2014. [IF 2.73]

[9] Li G, Yan W, Qiao Q, Chen J, Cai F, He Y, Zhang X*. Global effects of subchronic treatment of microcystin-LR on rat splenetic protein levels. J. Proteomics 77: 383-393. 2012a. [IF 5.07]

[10] Li G, Cai F, Yan W, Li CR, Wang JH*. A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease. Toxicol. Sci. 127(2): 485-495. 2012b. [IF 5.09]  

[11] Liu CS, Yan W, Zhou BS, Guo YY, Liu HL, Yu HX, Giesy JP, Wang JH, Li GY*, Zhang XW*. Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos. Aquat. Toxicol. 118: 108-115. 2012. [IF 3.72] (共同通讯作者)  

[12] Yan W, Zhou Y, Yang J, Wang JH, Chen J*, Li GY*. Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis in zebrafish larvae. Chemosphere 87(11): 1301-1307. 2012. [IF 3.15] (共同通讯作者)

[13] Li GY, Chen J, Xie P*, Jiang Y, Wu LY, Zhang XZ. Protein profiles in zebrafish (Danio rerio) embryos exposed to microcystin-LR. Proteomics 11:2003-2018. 2011. [IF 4.82]  

[14] Li GY, Shen D, Liang XF*, He Y, He S. Effects of malachite Green on the mRNA expression of detoxification-related genes in Nile tilapia (Oreochromis niloticus) and other major Chinese freshwater fishes. Environ. Toxicol. 28: 137-145. 2013. [IF 2.40] (共同第一作者)  

[15] Li GY, Xie P*, Li HY, Hao L, Xiong Q, Qiu T. Acute effects of microcystins on the transcription of 14 glutathione S-transferase isoforms in Wistar rat. Environ. Toxicol. 26:187-194. 2011. [IF 1.83]  

[16] Li GY, Xie P*, Li HY, Hao L, Xiong Q, Qiu T, Liu Y. Involment of p53, Bax, and Bcl-2 pathway in microcystins-induced apoptosis in rat testis. Environ. Toxicol. 26:111-117. 2011. [IF 1.83]  

[17] Li GY, Xie P*, Li HY, Chen J, Hao L, Xiong Q. Quantitative profiling of mRNA expression of glutathione S-transferase superfamily genes in various tissues of bighead carp (Aristichthys nobilis). J. Biochem. Mol. Toxicol. 24:250-259. 2010. [IF 1.96]  

[18] Li GY, Xie P*, Fu J, Hao L, Xiong Q, Li HY. Microcystin-induced variations in transcription of GSTs in an omnivorous freshwater fish, goldfish. Aquat. Toxicol. 88:75-80. 2008. [IF 3.52 ]  

 

备注 近五年受到国家自然基金青年基金、面上基金,教育部新教师基金、霍英东基金以及湖北省基金资助。