李广宇 【副教授】

姓名 李广宇 性别 照片
职称 副教授 学位 博士
电话 13407195245 邮箱 liguangyu@mail.hzau.edu.cn
工作单位 华中农业大学水产学院
研究方向 毒理生态及环境健康
教育经历 教育经历(按时间倒排序):
2005/9 - 2010/7,中国科学院水生生物研究所,水生生物学,博士,导师:谢平
2001/9 - 2005/7,华中师范大学,生物技术,学士
主要职历 工作经历(科研与学术工作经历,按时间倒序排序):
2016/3-2017/3,加州大学戴维斯分校,访问学者
2012/12 - 至今,华中农业大学,水产学院,副教授
2010/7-2012/12,华中农业大学,水产学院,讲师
科研成果

主持或参加科研项目及人才计划项目情况:

  [1] 国家自然科学基金面上项目、31570510、《微囊藻毒素的母代转移途径及其诱发子代神经毒性的机制研究》2016/1-2019/12、资助金额:63.0万元、主持。

  [2] 霍英东教育基金青年教师基金(教育部人才项目)、141078、《孕期微囊藻毒素暴露诱发胎鼠发育迟缓的分子机制》、2014/1-2015/12、资助金额:11.0万元、在研、主持。

  [3] 国家自然科学青年基金、31200402、《微囊藻毒素的母体传递效应对斑马鱼子代胚胎发育的影响》、2013/1-2015/12、资助金额:21.0万元、结题、主持。

  [4] 教育部新教师基金、20120146120008、《环境浓度微囊藻毒素暴露诱发斑马鱼子代胚胎发育毒性的分子机制》、2013/1-2014/12、资助金额:4.0万元、已结题、主持。

  [5] 湖北省自然科学基金、2011CDB151、《微囊藻毒素诱发斑马鱼胚胎细胞凋亡的分子机制研究》、2011/1-2012/12、资助金额:2.0万元、已结题、主持。

  发表论文(第一及通讯作者):

1.Wu Q, Yan W, Cheng HC, Liu CS, Hung TC, Guo XC, Li GY*. 2017. Parental transfer of microcystin-LR induced transgenerational effects of developmental neurotoxicity in zebrafish offspring. Environ. Pollut. 231(Pt 1):471-478. doi: 10.1016/j.envpol.2017.08.038. [IF 5.10]

2.Cheng HC, Yan W, Wu Q, Liu CS, Gong XY, Hung TC, Li GY*. 2017. Parental exposure to microcystin-LR induced thyroid endocrine disruption in zebrafish offspring, a transgenerational toxicity. Environ. Pollut. 230, 981-988. doi: 10.1016/j.envpol.2017.07.061. [IF 5.10]

3.Li GY#, Ye HK, Su GY, Han ZH, Xie CX, Zhou BS, Letcher RJ, Giesy JP, Yu HX, Liu CS. 2017. Establishment of a three-step method to evaluate effects of chemicals on development of zebrafish embryo/larvae. Chemosphere 186, 209-217 [IF 4.208]

4.Wu Q, Yan W, Liu CS, Li L, Yu L, Zhao SJ, Li GY*. 2016. Microcystin-LR exposure induces developmental neurotoxicity in zebrafish embryo. Environ. Pollut. 213, 793-800. [IF 5.10]

5.He J #, Li GY #, Chen J #, Lin J, Zeng C, Chen J, Deng J, Xie P*. 2017. Prolonged exposure to low‑dose microcystin induces nonalcoholic steatohepatitis in mice: a systems toxicology study. Arch. Toxicol. 91, 465-480. [IF 5.901]

6.Li GY#, Yan W, Dang Y, Li J, Liu CS, Wang J*. 2015. The role of calcineurin signaling in microcystin-LR triggered neuronal toxicity. Scientific Reports, 5:11271. [IF 5.228]

7.Li J, Giesy JP, Yu L, Li GY*, Liu CS*. 2015. Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Tetrahymena Thermophila: targeting the ribosome. Scientific Reports, 5:10562. [IF 5.228]

8.Xie L, Yan W, Yu L, Wang J, Li GY*, Chen N*, Alan DS. 2015. Microcystin-RR exposure results in growth impairment by disrupting thyroid endocrine in zebrafish larvae. Aquat. Toxicol. 164:16-22. [IF 3.557]

9.Zhao SJ, Li G*, Chen J*. 2015. A proteomic analysis of prenatal transfer of microcystin-LR induced neurotoxicity in rat offspring. J. Proteomics 114: 197-213. [IF 3.867]

10.Zeng C, Sun H, Xie P, Wang JH, Zhang GR, Chen N, Yan W*, Li GY*. 2014. The role of apoptosis in MCLR-induced developmental toxicity in zebrafish embryos. Aquat. Toxicol. 149: 25-32. [IF 3.73]

11.Li GY, Yan W, Cai F, He Y, Chen N, Wang JH*.2014. Spatial learning and memory impairment and pathological change in rats induced by acute exposure to microcystin-LR. Environ. Toxicol. 29: 261-268. [IF 3.193]

12.Li G, Yan W, Qiao Q, Chen J, Cai F, He Y, Zhang X*. 2012. Global effects of subchronic treatment of microcystin-LR on rat splenetic protein levels. J. Proteomics 77: 383-393. [IF 4.088]

13.Li G, Cai F, Yan W, Li CR, Wang JH*. A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease. Toxicol. Sci. 127(2): 485-495. 2012b. [IF 5.09]

14.Liu CS, Yan W, Zhou BS, Guo YY, Liu HL, Yu HX, Giesy JP, Wang JH, Li GY*, Zhang XW*. Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos. Aquat. Toxicol. 118: 108-115. 2012. [IF 3.72]

15.Yan W, Zhou Y, Yang J, Wang JH, Chen J*, Li GY*. Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis in zebrafish larvae. Chemosphere 87(11): 1301-1307. 2012. [IF 3.15]

16.Li GY, Chen J, Xie P*, Jiang Y, Wu LY, Zhang XZ. Protein profiles in zebrafish (Danio rerio) embryos exposed to microcystin-LR. Proteomics 11:2003-2018. 2011. [IF 4.82]

17.Li GY, Shen D, Liang XF*, He Y, He S. Effects of malachite Green on the mRNA expression of detoxification-related genes in Nile tilapia (Oreochromis niloticus) and other major Chinese freshwater fishes. Environ. Toxicol. 28: 137-145. 2013. [IF 2.40]

18.Li GY, Xie P*, Li HY, Hao L, Xiong Q, Qiu T. Acute effects of microcystins on the transcription of 14 glutathione S-transferase isoforms in Wistar rat. Environ. Toxicol. 26:187-194. 2011. [IF 1.83]

19.Li GY, Xie P*, Li HY, Hao L, Xiong Q, Qiu T, Liu Y. Involment of p53, Bax, and Bcl-2 pathway in microcystins-induced apoptosis in rat testis. Environ. Toxicol. 26:111-117. 2011. [IF 1.83]

20.Li GY, Xie P*, Li HY, Chen J, Hao L, Xiong Q. Quantitative profiling of mRNA expression of glutathione S-transferase superfamily genes in various tissues of bighead carp (Aristichthys nobilis). J. Biochem. Mol. Toxicol. 24:250-259. 2010. [IF 1.96]

21.Li GY, Xie P*, Fu J, Hao L, Xiong Q, Li HY. Microcystin-induced variations in transcription of GSTs in an omnivorous freshwater fish, goldfish. Aquat. Toxicol. 88:75-80. 2008. [IF 3.52 ]

专利:

王江华 李广宇 袁勇超 党? 李静;一种适用于双向电泳的大鼠海马全蛋白提取与分离的方法

备注 师风师德奖励:
2017年度:华中农业大学“渔经奖教金”;
2017年度:华中农业大学“教学质量三等奖”;
2017年度:华中农业大学水产学院“年度先进个人”;
2015年度:华中农业大学水产学院“讲课竞赛第三名”
2013年度:华中农业大学水产学院“讲课竞赛第二名”
2013学度:华中农业大学“校级优秀班主任”;
2012-2013年度:华中农业大学水产学院“教书育人奖”
教研教改项目:
2015年,校级教学研究项目 “基础生物化学实验课件ppt的美化与应用 
2015-2017年,校级重点建设课程项目 “基础生物化学”重点课程建设    
2016-2017年,校级百门精品实践课程建设项目“动物基础生物化学实验”