刘春生 【教授】

姓名 刘春生 性别 照片
职称 教授 学位 博士
电话 13638666275 邮箱 cliu@mail.hzau.edu.cn
工作单位 华中农业大学水产学院
研究方向 水生态毒理学,水体化学污染物对渔业资源的影响
教育经历 2008年9月—2011年6月    中科院水生生物研究所         生态毒理学(博士)
2006年9月—2008年9月    中科院水生生物研究所         生态毒理学(硕转博)
2009年6月—2009年11月   加拿大萨省大学毒理学中心     学术交流(硕士期间)
2002年9月—2006年7月    东北大学                     生物工程(本科)
主要职历 2016年8月-至今:华中农业大学,教授,博导
2013年12月—2016年8月:华中农业大学,研究员,博导
2013年1月—2013年12月:新加坡国立大学,博后
2011年8月—2012年12月:南京大学, 助理研究员


科研成果

科研项目:

(5)国家自然科学基金面上项目,环境相关浓度TDCIPP暴露对土著鲫鱼的发育繁殖毒性研究,2019/1-2022/12,在研,主持。

(4)国家重点研发计划“化学品健康危害快速分级与确证技术研究”,2017/7-2020/12,在研,参加。

(3)国家自然科学基金优秀青年基金,水生态毒理学,2017/1-2019/12,在研,主持。

(2)华中农业大学人才建设费,高层次引进人才科研启动经费,2013/12-2018/12,在研,主持。

(1)国家自然科学基金青年基金,建立斑马鱼胚胎胁迫通路基因分析平台研究典型有机磷阻燃剂发育毒性的分子机制,2013/01-2015/12,结题,主持。

代表作(*通讯作者):

(35) Yao Dang, Qian Sun, Robert J. Letcher, Chunsheng Liu* (2018). Unexpected observations: exposure to aromatase inhibitor prochloraz did not alter vitellogenin content in zebrafish ova, but inhibited growth of larval offspring. Environmental Science & Technology Letters, 5, 629-634.

(34) Rui Zhang, Xiaoxiang Wang, Xuesheng Zhang, Junjiang Zhang, Xiaowei Zhang, Xiao Shi, Doug Crump, Robert J. Letcher, John P. Giesy, Chunsheng Liu* (2018). Down-regulation of hspb9 and hspb11 contributes to wavy notochord in zebrafish embryos following exposure to polychlorinated diphenylsulfides. Environmental Science & Technology, 52, 12829-12840.

(33) Rui Zhang, Xiaoxiang Wang, Xuesheng Zhang, Chao Song, Robert J. Letcher, Chunsheng Liu* (2018). Polychlorinated diphenylsulfides activate aryl hydrocarbon receptor 2 in zebrafish embryos: potential mechanism of developmental toxicity. Environmental Science & Technology, 52, 4402-4412.

(32) Ya Zhu, Daohui Lin, Dandong Yang, Yali Jia, Chunsheng Liu* (2018). Environmentally relevant concentrations of the flame retardant tris(1,3-dichloro-2-propyl) phosphate change morphology of female zebrafish. Chemosphere, 212, 358-364.

(31) Yao Dang, Fei’er Wang, Chunsheng Liu* (2018). Real-time PCR array to study the effects of chemicals on the growth hormone/insulin-like growth factors (GH/IGF) axis of zebrafish embryos/larvae. Chemosphere, 207, 365-376.

(30) Yongkang Zhang, Guanyong Su, Meng Li, Shuying Li, Qiangwei Wang, Guonian Zhu, Robert J. Letcher, Chunsheng Liu* (2018). Chemical and biological transfer: which one is responsible for the maternal transfer toxicity of tris(1,3-dichloro-2-propyl) phosphate in zebrafish? Environmental Pollution, 243, 1376-1382.

(29) Yongkang Zhang, Meng Li, Shuying Li, Qiangwei Wang, Guonian Zhu, Guanyong Su, Robert J. Letcher, Chunsheng Liu* (2018). Exposure to tris(1,3-dichloro-2-propyl) phosphate for two generations decreases fecundity of zebrafish at environmentally relevant concentrations. Aquatic Toxicology, 200, 178-187.

(28) Siliang Yuan, Han Li, Yao Dang, Chunsheng Liu* (2018). Effects of riphenyl phosphate on growth, reproduction and transcription of genes of Daphnia magna. Aquatic Toxicology, 195, 58-66.

(27) Han Li, Siliang Yuan, Guanyong Su, Meng Li, Qiangwei Wang, Guonian Zhu, Robert J. Letcher, Yufei Li, Zhihua Han, Chunsheng Liu* (2017). Whole-life-stage characterization in the basic biology of Daphnia magna and effects of TDCIPP on growth, reproduction, survival and transcription of genes. Environmental Science & Technology, 51, 13967-13975.

(26) Guangyu Li, Huike Ye, Guanyong Su, Zhihua Han, Congxin Xie, Bingsheng Zhou, Robert J. Letcher, John P. Giesy, Hongxia Yu, Chunsheng Liu* (2017). Establishment of a three-step method to evaluate effects of chemicals on development of zebrafish embryo/larvae. Chemosphere, 186, 209-217.

(25) Ya Zhu, Guanyong Su, Dandong Yang, Yongkang Zhang, Liqin Yu, Yufei Li, John P. Giesy, Robert J. Letcher, Chunsheng Liu* (2017). Time-dependent inhibitory effects of tris(1,3-dichloro-2-propyl) phosphate on growth and transcription of gene involved in the GH/IGF axis, but not the HPT axis, in female zebrafish. Environmental Pollution, 229, 470-478.

(24) Liqin Yu, Yali Jia, Guanyong Su*, Yongkai Sun, Robert J. Letcher, John P. Giesy, Hongxia Yu, Zhihua Han, Chunsheng Liu* (2017). Parental transfer of tris(1,3-dichloro-2-propyl) phosphate and transgenerational inhibition of growth of zebrafish exposed to environmentally relevant concentrations. Environmental Pollution, 220, 196-203.

(23) Shiyang Cheng, Jing Li, Guanyong Su, Robert J. Letcher, John P. Giesy, Chunsheng Liu* (2016). A reagent-free screening assay for evaluation of the effects of chemicals on the proliferation and morphology of Hela-GFP cells. Environmental Science & Technology Letters, 3, 322-326.

(22) Jing Li, Xufa Ma, Guanyong Su*, John P. Giesy, Yuan Xiao, Bingsheng Zhou, Robert J. Letcher, Chunsheng Liu* (2016). Multigenerational effects of tris(1,3-dichloro-2-propyl) phosphate on the free-living ciliate protozoa Tetrahymena thermophile exposed to environmentally relevant concentrations and after subsequent recovery. Environmental Pollution, 218, 50-58.

(21) Yao Dang, Jianghua Wang, John P. Giesy, Chunsheng Liu* (2016). Responses of the zebrafish hypothalamic-pituitary-gonadal-liver axis PCR array to prochloraz are dependent on timing of sampling. Aquatic Toxicology, 175, 154-159.

(20) Chunsheng Liu*, Guanyong Su, John P. Giesy, Robert J. Letcher, Guangyu Li, Ira Agrawal, Jing Li, Liqin Yu, Jianghua Wang, Zhiyuan Gong* (2016). Acute exposure to tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) causes hepatic inflammation and leads to hepatotoxicity in zebrafish. Scientific Reports, 6:19045.

(19) Ya Zhu, Xufa Ma, Guanyong Su*, Liqin Yu, Robert J. Letcher, Jie Hou, Hongxia Yu, John P. Giesy, Chunsheng Liu* (2015). Environmentally relevant concentrations of the flame retardant tris(1,3-dichloro-2-propyl) phosphate inhibit growth of female zebrafish and decrease fecundity. Environmental Sciences & Technology, 49, 14579-14587.

(18) Han Li, Guanyong Su, Ming Zou, Liqin Yu, Robert J. Letcher, Hongxia Yu, John P. Giesy, Bingsheng Zhou, Chunsheng Liu* (2015). Effects of tris(1,3-dichloro-2-propyl) phosphate on growth, reproduction, and gene transcription of Daphnia magna at environmentally relevant concentrations. Environmental Sciences & Technology, 49, 12975-12983.

(17) Jing Li, John P. Giesy, Liqin Yu, Guangyu Li*, Chunsheng Liu* (2015). Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Tetrahymena Thermophila: targeting the ribosome. Scientific Reports, 5:10562.

(16) Yao Dang, John P. Giesy, Jianghua Wang*, Chunsheng Liu* (2015). Dose-dependent compensation responses of the hypothalamic-pituitary-gonadal-liver axis of zebrafish exposed to the fungicide prochloraz. Aquatic Toxicology, 160, 69-75.

(15) Liqin Yu, Zhihua Han*, Chunsheng Liu* (2015). A review on the effects of PBDEs on thyroid and reproduction systems in fish. General and Comparative Endocrinology, 219, 64-73. invited review

(14) Zhihua Han, Qiangwei Wang, Jie Fu, Hongshan Chen, Ye Zhao, Bingsheng Zhou, Zhiyuan Gong, Si Wei, Jun Li, Hongling Liu, Xiaowei Zhang, Chunsheng Liu*, Hongxia Yu* (2014). Multiple bio-analytic methods to reveal possible molecular mechanisms of developmental toxicity in zebrafish embryos/larvae exposed to tris(2-butoxyethyl) phosphate. Aquatic Toxicology, 150, 175-181.

(13) Jie Fu, Changpo Zhao, Yupeng Luo, Chunsheng Liu*, George Z. Kyzas, Yin Luo, Dongye Zhao, Shuqing An, Hailiang Zhu* (2014). Heavy metals in surface sediments of the Jialu River, China: their relations to environmental factors. Journal of Hazardous Materials, 270, 102-109.

(12) Chunsheng Liu*, Hongyan Xu, Siew Hong Lam, Zhiyuan Gong* (2013). Selection of reliable biomarkers from PCR array analysis using relative distance computational model: methodology and proof-of-concept study. PLoS ONE, e83954.

(11) Chunsheng Liu, Hongxia Yu, Xiaowei Zhang (2013). Zebrafish embryos/larvae for rapid determination of effects on hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-interrenal (HPI) axis: mRNA expression. Chemosphere, 93, 2327−2332.

(10) Jie Fu, Jian Han, Bingsheng Zhou, Zhiyuan Gong, Eduarda M. Santos, Xiaojing Huo, Weiling Zheng, Hongling Liu, Hongxia Yu, Chunsheng Liu* (2013). Toxicogenomic responses of zebrafish embryos/larvae to tris(1,3-dichloro-2-propyl) phosphate (TDCPP) reveal possible molecular mechanisms of developmental toxicity. Environmental Sciences & Technology, 47, 10574−10582.

(9) Chunsheng Liu*, Qiangwei Wang, Kang Liang, Jingfu Liu, Bingsheng Zhou, Xiaowei Zhang, Hongling Liu, John P. Giesy, Hongxia Yu* (2013). Effects of tris(1,3-dichloro-2-propyl) phosphate and triphenyl phosphate on receptor-associated mRNA expression in zebrafish embryos/larvae. Aquatic Toxicology, 128-129, 147-157.

(8) Qiangwei Wang, Kang Liang, Jingfu Liu, Lihua Yang, Yongyong Guo, Chunsheng Liu*, Bingsheng Zhou* (2013). Exposure of zebrafish embryos/larvae to TDCPP alters concentrations of thyroid hormones and transcriptions of genes involved in the hypothalamic-pituitary-thyroid axis. Aquatic Toxicology, 126, 207-213.

(7) Chunsheng Liu, Wei Yan, Bingsheng Zhou, Yongyong Guo, Hongling Liu, Hongxia Yu, John P. Giesy, Jianghua Wang, Guangyu Li, Xiaowei Zhang (2012). Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-Propyl-2-thiouracil in zebrafish embryos. Aquatic toxicology, 118, 108-115 .

(6) Chunsheng Liu, Xiaowei Zhang, Jun Deng, Markus Hecker, John P. Giesy, Bingsheng Zhou (2011). Effects of prochloraz or propylthiouracil on the cross-talk between the HPG, HPA and HPT axes in zebrafish. Environmental Sciences &Technology , 45, 769-775.

(5) Chunsheng Liu, Jun Deng, Liqin Yu, Mathan Ramesh, Bingsheng Zhou (2010). Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 FTOH fluorotelomer alcohol. Aquatic toxicology, 96, 70-76.

(4) Chunsheng Liu, Xiaowei Zhang, Hong Chang, Paul Jones, Steve Wiseman, Jonathan Naile, Markus Hecker, John P. Giesy, Bingsheng Zhou (2010). Effects of fluorotelomer alcohol 8:2 FTOH on steroidogenesis in H295R cells: Targeting the cAMP signaling cascade. Toxicology and Applied Pharmacology, 247, 222-228.

(3) Chunsheng Liu, Liqin Yu, Jun Deng, Paul K.S. Lam, Rudolf S.S. Wu, Bingsheng Zhou (2009). Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic-pituitary-gonadal (HPG) axis in zebrafish. Aquatic toxicology, 93, 131-137.

(2) Chunsheng Liu, Yongbing Du, Bingsheng Zhou (2007). Evaluation of estrogenic activities and mechanism of action of perfluorinated chemicals determined by vitellogenin induction in primary cultured tilapia hepatocytes. Aquatic Toxicology, 85, 267-277.

(1) Chunsheng Liu, Ke Yu, Xiongjie Shi, Jingxian Wang, Paul K.S. Lam, Rudolf S.S. Wu and Bingsheng Zhou (2007).Induction of oxidative stress and apoptosis by PFOS and PFOA in primary cultured hepatocytes of freshwater tilapia (Oreochromis niloticus). Aquatic Toxicology, 82, 135-143.

备注 (2)2016年:获得国家基金委优秀青年基金的资助。
(1)2014年:入选湖北省楚天学子;